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Panic disorder is a common anxiety disorder, which is associated with high subjective burden as well as a high cost for the health economy. According to the National Treatment Guideline S3, cognitive behavior therapy is recommended as the most effective psychological treatment. However, many people in need do not have access to cognitive behavior therapy. Internet-based interventions have proven to be an effective way to provide access to evidence-based treatment to those affected. For anxiety disorders, such as panic disorder and agoraphobia, a good effectiveness of internet-based interventions has been proven in numerous international studies. However, the internet has changed over the last few years: mobile technologies have considerable potential to further improve the adherence and effectiveness of internet-based interventions. Against this background, the authors developed the hybrid online training "GET.ON Panic". In this training, an app has been integrated into a browser-based online training. The app consists of a mobile diary for self-monitoring as well as a mobile exposure-guide that supports participants in self-exposure exercises in their everyday lives.In an initial exploratory feasibility study, qualitative interview data and quantitative measurements were collected in a pre-post design of 10 participants. Usage, user friendliness, user satisfaction and acceptance of the app were generally considered high. The use of interoceptive exposure exercises and daily summaries of anxiety and mood were the most widely performed and rated the best, while in vivo exposure exercises and the monitoring of acute panic symptoms were found to be difficult.In the efficacy study, 92 participants with mild to moderate panic symptoms were randomized into two parallel groups. After eight weeks, the intervention group showed a significant improvement in the severity of panic symptoms compared to the waiting control group. Using the intention-to-treat approach, a covariance analysis with baseline values as a covariate yielded a mean effect of Cohen's d=0.66 in reducing the panic symptoms in favor of the intervention group. This effect increased to d=0.89 after three months and stayed at d=0.81 at the 6-month measurement point. Response and remission rates were also significantly higher in the intervention group. This positive effect was also shown for secondary outcomes such as depressive symptoms and quality of life. A correlation between app usage and clinical outcomes could not be found. This work was the first to demonstrate that a hybrid online training based on cognitive behavior therapy is effective in reducing panic symptoms as well as panic disorder. In addition, this work contributes to a deeper understanding of the potential of mobile technologies in the field of e-mental health.