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The principle of this thesis was to study the environmental fate of three highly used psychotropic drugs and this achieved through: 1) examining the biodegradability of TMI, DMI and CPTX, 2) studying the behaviour of TMP, DMI and CPTX in photodegradation tests using Xe and UV lamps with studying the effect of different environmental conditions on their UV-photodegradation behaviour, 3) monitoring the primary elimination of TMP, DMI and CPTX during photodegradation and biodegradation tests using HPLC, and measuring their degree of mineralization by means of dissolved organic carbon analyser (DOC), 4) elucidating the structures of the transformation products (TPs) which formed during the degradation of TMI, DMI and CPTX by using LC-MS/MS analysis, 5) analysing the biodegradability of their TPs by laboratory tests and in-silico assessments in order to determine the fate and persistence of these TPs in the aquatic environment, 6) conducting in-silico toxicity predictions for the selected psychotropic drugs and their TPs in human (carcinogenicity, genotoxicity and mutagenicity) and in eco-system (toxicity to microorganisms and toxicity in rainbow trouts). As an overall conclusion, the present work demonstrates that a combination of laboratory simulation tests, LC-MS/MS analysis and in-silico tools result in valuable new information regarding environmental fate of three important psychotropic drugs and their TPs. This dissertation also highlights that different environmental conditions such as temperature, initial drug concentration and pH can differently affect the degradation behaviour of pharmaceuticals even when they are highly structurally related. Therefore, one cannot conclude from one pharmaceutical to another but each one needs to be investigated individually and this present a great challenge for risk assessment kinetics of chemicals in the aquatic environment. The results presented here showed that the investigated pharmaceuticals and their TPs can negatively affect the environment which may be harmful to the ecosystem as they might have been present for decades in the aquatic environment without any knowledge of their environmental fate or connected risk. Therefore, further work needs to be done including analysis of environmental samples (e.g., surface waters), as well as laboratory toxicity tests to further expand knowledge on their exact environmental impact.
Exploring artful possibilities: a transdisciplinary research on culture, arts and sustainability
(2021)
The texts gathered in this manuscript offer a largely congruent set of insights on the cultural dimension of sustainability and on the important functions of the arts in relation to the cultural dimension of sustainability, not only in society – more particularly in cities – but also more self- reflexively in transdisciplinary sustainability research itself. The introduction paper (original text for the Cumulative Habilitation) presents all the published texts included in the cumulative habilitation manuscript, and discusses the challenges of transdisciplinary research, differentiating two schools of transdisciplinarity (the so-called the ‘ETH’ and ‘CIRET’ approaches) to which the author’s postdoctoral research relates. The four texts in the first part (PART 1 - Culture(s) and Aesthetics of sustainability)articulate the relations between culture and sustainability. They focus on a theoretical dimension of the author’s postdoctoral research that further developed an understanding of “cultures of sustainability” and of “aesthetics of complexity” that was initiated in the author’s PhD, bringing them in a dialogue with other ongoing and emerging discourses about “cultural sustainability” and “queer ecologies”. The four texts in the second part (PART 2 - The Arts in Relation to Culture(s) and Aesthetics of Sustainability) represent the part of the author’s research that constituted a closer examination of specific artistic practices: ecological art, musical practices, and contemporary interdisciplinary arts in urban arts organizations.
The ten texts in the third part (PART 3 - Creative Sustainable Cities) share the insights gained in the parts of the author’s research work that focused on urban cultural and arts-related phenomena in their relationships to urban sustainability. Several of the texts lay out a critique of the “Creative City” and demonstrate an effort to develop an alternative understanding of the Creative City that would deserve to be also named a “Sustainable City”. Later texts share the insights from the author’s co-leading of the “Stadt als Möglichkeitsraum” (“City as Space of Possibilities”) research project (2015-2018).
The nine texts collected in the fourth part (PART 4 - Towards Artful Sustainability Research)reflect how the author’s ongoing research work included a transdisciplinary reflection and development in terms of epistemology and methodology, incorporating increasingly more elements of arts-based research and of phenomenology and integrating them with systems thinking and qualitative social-scientific research. This development brought the author to reflect further upon the imaginaries and research practices of sustainability researchers, and to advocate for an “artistic turn” in sustainability research (including the more specific field of sustainability science).
The conclusion paper (original text for the Cumulative Habilitation) summarizes the insights from all the published texts included in the cumulative habilitation manuscript, and suggests ways to address the transdisciplinary challenges presented in the introduction paper, suggesting ways to articulate the ‘ETH’ and ‘CIRET’ approaches to transdisciplinarity.
Mental health is an important factor in an individuals' life. Online-based interventions have been developed for the treatment of various mental disorders. During these interventions, a large amount of patient-specific data is gathered that can be utilized to increase treatment outcomes by informing decision-making processes of psychotherapists, experts in the field, and patients. The articles included in this dissertation focus on the analysis of such data collected in digital psychological treatments by using machine learning approaches. This dissertation utilizes various machine learning methods such as Bayesian models, regularization techniques, or decision trees to predict different psychological factors, such as mood or self-esteem, dropout of patients, or treatment outcomes and costs. These models are evaluated using a variety of performance metrics, for example, receiver operating characteristics curve, root mean square error, or specialized performance metrics for Bayesian inference. These types of analyses can support decision- making for psychologists and patients, which can, in turn, lead to better recommendations and subsequently to increased outcomes for patients and simultaneously more insight about the interplay between psychological factors. The analysis of user journey data has not yet been fully examined in the field of psychological research. A process for this endeavor is developed and a technical implementation is provided for the research community. The application of machine learning in this context is still in its infancy. Thus, another contribution is the exploration and application of machine learning techniques for the revelation of correlations between psychological factors or characteristics and treatment outcomes as well as their prediction. Additionally, economic factors are predicted to develop a process for treatment type recommendations. This approach can be utilized for finding the optimal treatment type for patients on an individual level considering predicted treatment outcomes and costs. By evaluating the predictive accuracy of multiple machine learning techniques based on various performance metrics, the importance of considering heterogeneity among patients' behavior and affect is highlighted in some articles. Furthermore, the potential of machine learning-based decision support systems in clinical practice has been examined from a psychotherapists' point of view.
A Matter of Connection: Competence Development in Teacher Education for Sustainable Development
(2021)
Based on a dual case study, this cumulative dissertation investigates how individual "education for sustainable development" (ESD) courses, as part of the teacher education programs at Leuphana University in Lüneburg/Germany and Arizona State University (ASU)/USA, actually foster students' ESD-specific professional action competence. Furthermore, this work sheds light on the link between learning processes and outcomes, to reveal which factors actually affect the achievement of ILOs and competence development. The findings of this study indicate that both courses under investigation eventually live up to their role and increased student teachers' competence and commitment to implement ESD in their future careers; yet, mainly due to their different thematic foci, to varying degrees. Additionally, the four Cs (personal, professional, social, and structural connections) were revealed as significant factors that support students' learning and should be considered when planning and designing course offerings in TESD, with the goal of developing students' knowledge, skills, and attitudes.
Assessment of forest functionality and the effectiveness of forest management and certification
(2021)
Forest ecosystems are complex systems that develop inherent structures and processes relevant for their functioning and the provisioning of ecosystem services that contribute to human wellbeing. With increasing climate change impacts, especially regulating ecosystem services such as microclimate regulation are ever more relevant to maintain forest functions and services. A key question is how forest management supports or undermines the ecosystems’ capacity to maintain those functions and services. The main objective of this thesis is the development of a concept to assess the functionality of forests and to evaluate the effectiveness of forest ecosystem management including certification. An ecosystem-based and participatory methodology, named ECOSEFFECT, was developed. The method comprises a theoretical and an empirical plausibility analysis. It was applied to the Russian National FSC Standard in the Arkhangelsk Region of the Russian Federation - where boreal forests are exploited to meet Europe's demand for timber. In addition, the influence of forestry interventions on temperature regulation in Scots pine and European beech forests in Germany was assessed during two extreme hot and dry years in 2018 and 2019. Microclimate regulation is a suitable proxy for forest functionality and can be applied easily to evaluate the effectiveness of forest management in safeguarding regulating forest functions relevant under climate change. Thus, the assessment of forest microclimate regulation serves as convenient tool to illustrate forest functionality. In the boreal and temperate forests studied in the frame of this thesis, timber harvesting reduced the capacity to self-regulate forests’ microclimate and thus impair a crucial part of ecosystem functionality. Changes in structural forest characteristics influenced by forest management and silviculture significantly affect microclimatic conditions and therefore forest ecosystems' vulnerability to climate change. Canopy coverage and the number of cut trees were most relevant for cooling maximum summer temperature in pine and beech forests in northern Germany. The Russian FSC standard has the potential to improve forest management and ecological outcomes, but there are shortcomings in the precision of targeting actual problems and ecological commitment. It is theoretically plausible that FSC prevents logging in high conservation value forests and intact forest landscapes, reduces the size and number of clearcuts, and prevents hydrological changes in the landscape. However, the standard was not sufficiently explicit and compulsory to generate a strong and positive influence on the identified problems and their drivers. Moreover, spatial data revealed, that the typical regular clearcut patterns of conventional timber harvesting continue to progress into the FSC-certified boreal forests, also if declared as "Intact Forest Landscape". This results in the need to verify the assumptions and postulates on the ground as it remains unclear and questionable if functions and services of boreal forests are maintained when FSC-certified clearcutting continues.The analysis of satellite-based data on tree cover loss showed that clearcutting causes secondary dieback in the surrounding of the cleared area. FSC-certification does not prevent the various negative impacts of clearcutting and thus fails to safeguard ecosystem functions. The postulated success in reducing identified environmental threats and stresses, e. g. through a smaller size of clearcuts, could not be verified on site. The empirical assessment does not support the hypothesis of effective improvements in the ecosystem. In practice, FSC-certification did not contribute to change clearcutting practices sufficiently to effectively improve the ecological performance. Sustainability standards that are unable to translate principles into effective outcomes fail in meeting the intended objectives of safeguarding ecosystem functioning. Clearcuts that carry sustainability labels are ecologically problematic and ineffective for the intended purpose of ecological sustainability.The overexploitation of provisioning services, i.e. timber extraction, diminishes the ecosystems' capacity to maintain other services of global significance. It also impairs ecosystem functions relevant to cope with and adapt to other stresses and disturbances that are rapidly increasing under climate change.