Human activities have become a major driver of global change, so that global society and economy are facing consequences such as climate change, increasing scarcity of resources, environmental pollution and degradation as well as disturbances of ecosystem functioning and services.In order to meet these main challenges in an appropriate way, adequate starting points and solutions must be pursued at all levels to shift the current socio-economic pathway from an unsustainable to a safe operating and thus sustainable development within the planetary boundaries. One of the application concepts in industrial contexts is Industrial Symbiosis (IS), which deals with the set-up of advanced circular/cascading systems, in which the energy and material flows are prolonged for multiple material and energetic (re-)utilization within industrial systems in order to increase resource productivity and efficiency, while reducing environmental impacts. The overarching goal of the research project was to identify and develop approaches to enable the evolution of Industrial Symbiosis (IS) in Industrial Parks (IPs). IS is a collaborative cross-sectoral approach to connect the resource supply and demand of various industries in order to optimize the resource use through exchange of materials, energy, water and human resources across different companies, while generating ecological, technical, social and economic benefits. Many Information Communication Technology (ICT) tools have been developed to facilitate IS, but they predominantly focus on the as-is analysis of the IS system, and do not consider the development of a common desired target vision or corresponding possible future scenarios as well as conceivable transformation paths from the actual to the defined (sustainability) target state. This gap shall be addressed in this work, presenting the software requirements engineering results for a holistic IT-supported IS tool covering system analysis, transformation simulation and goal-setting. This study also aims to present the conceptual IT-supported IS tool and its corresponding prototype, developed for the identification of IS opportunities in IPs. This IS tool serves as an IS facilitating platform, providing transparency among market players and proposing potential cooperation partners according to selectable criteria (e.g. geographical radius, material properties, material quality, purchase quantity, delivery period). Therefore a quantitative indicator system was compiled and recurring patterns were identified to utilize this knowledge in the comprehensive IT-supported IS tool. So this IS tool builds the technology-enabled environment for the processes of first screening of IS possibilities and initiation for further complex business-driven negotiations and agreements for long-term IS business relationships.